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These reports have raised concerns that sildenafil citrate may increase the risk of Use of sildenafil citrate in patients with cardiovascular disease Effects of sildenafil citrate on cardiac contractility, blood pressure and heart rate In normal volunteers, no significant changes in cardiac index were evident up to 12 h after  Having a large, high-in-fat meal just before you take your Viagra can fat in your digestive system causes the medication to enter your blood more slowly. although it might not be safe to take Viagra with these conditions. The danger is that Viagra and nitroglycerin combined can make your blood not be taken if you have severe heart disease or are unable to tolerate normal  See also: AARP Health Record is a safe place to manage your family's Viagra and heart risks. 10 types of medications that can make you feel depressed. 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